Page 174 - CW E-Magazine (10-9-2024)

Special Report

The emphasis is on sustainability, reaction spherical agglomeration etc. The influen- made by mining natural materials such as
efficiency and seamless implementations. ces of crucial parameters were studied. slate or shale. There are many problems
These authors have reported isolated yield Thus, the viability was established. (Org. associated with using the above materials.
of 44% following concomitant distilla- Proc. Res. Dev., 2024, DOI: 10.1021/acs.
tion – crystallisation. Flow chemistry oprd.4c00181). SusMax – a startup company funded by
was adopted. The starting material is US NSF – have addressed the above prob-
Z-piperidine carboxylic acid, which go Development of a solid-compati- lem of using mixed materials by utilising
through some steps and lithiation involv- ble continuous flow reactor for waste coal ash. Engineered lightweight
ing 2,6-dimethylaniline. (Green Chem., the paraformaldehyde (PF) aggregates have been made. A thermo-
2024, DOI:101039/D3GC04375D). slurry mediated α-hydroxy- dynamic analysis has been done to ensure
methylation of methyl vinyl that the gas release is appropriate for crea-
A novel, industrially-feasible ketone (MVK) ting pores and trial and error is avoided.
synthetic route to (+)- biotin (B) (Chem. Eng. Progress, 2024, January).
from L-Cysteine (C) B. Vandekerckhove et al have referred to
the importance of α-hydroxymethylation Mechanochemically promoted
Q. Zhang et al have carried out the title reactions in the pharma industry. Aqueous functionalisation of post-con-
transformation via the known thiolactone HCHO solution take long time and sumer poly(methyl methacry-
intermediate. Advantage is taken of the gaseous HCHO is toxic. PF can solve the late) and poly(alpha-methylsty-
in-built stereochemistry of the starting problem by offering safety and ease of rene) for bulk depolymerisation
material C. C is converted to a hydan- handling. Continuous flow was adopted
toin avoiding racemisation followed and in situ depolymerisation of PF was J.B. Young et al have utilised mechano-
by catalytic cyanation, etc. (Helvetica invoked. The title reaction was carried out chemical macro-radical regeneration by
Chimica Acta, 2024, DOI: 10.1002/ successfully and optimised, resulting in a harnessing ultrasonication chain-scission
hca.2024.00090). Space Time Yield (STY) of 2,040 kg per in the presence of N-hydroxyphthilimide
Process intensification via end- hr. per cum. (Reaction Chem. Eng., 2024, methacrylate (PhthMA) to depoly-
merise title polymers. This strategy
to-end continuous manufactur- DOI: 10.1039/D4RE00220B). can be efficiently used for ultra-high
ing of Atorvastatin Ca using an Recycling waste coal ash pro- molecular weight polymers. (Angew.
integrated, modular reaction – mises more sustainable concrete Chem. Intl. Ed., 2024, DOI: 10.1002/
crystallisation – spherical agglo- materials acie.202408592).
meration – filtration – drying
NSF (USA) and Chem. Eng. Prog. (CEP) Conversion of mesitylene (M)
R. Parvaresh and Z.K. Nagy have un- have jointly written this paper under the to 3,5-dimethylbenzaldehyde
dertaken the title daunting task for the title “Catalysing commercialisation.” (DMB)
blockbuster drug (brand name Lipitor). Lightweight aggregates are used in the
FDA supports continuous processes. construction industry due to bulk density X. Zhan and Z. Ullah have explored the
There were a number of stumbling prob- lower than normal aggregates due to its role of nitric acid in photocatalytic con-
lems in the novel task undertaken. Process porous structure – for applications such as version of the title reaction in synergy
intensification was realised by a holistic lightweight concrete, insulating concrete, with phosphorous carrole. The optimal
integration of novel equipment design and fire-resistant concrete. The above conc. of HNO was 0.2M for maximising
3
such as oscillatory flow crystallisers, types of light aggregate are typically the yield of DMB. Mechanistic aspects
are discussed. (Molecular Catalysis,
2024, 563, June, 114229; DOI: 10.1016/j.
mcat.2024.114229).
Thermal risk assessment of
the complex nitration process
through safely operating space
analysis and optimisation

X. Tao et al have discussed the prob-
lems associated with thermal runaway

174 Chemical Weekly September 10, 2024

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