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ROMA ORGANICS PVT. LTD.                                                          Special Report
 Auth. Distributors of:
 M/s. Arkema Peroxides (I) P. Ltd.
   Luperox TBH70  Tertiary Butyl Hydro Peroxide (TBHP)
   Luperox CU90  Cumene Hydro Peroxide (CHP)  A rapid wrap-up of what’s new in Operations,
   Luperox P  Tertiary Butyl Per Benzoate (TBPB)
   Luperox A75  Benzoyl Peroxide (BPO)  Processes and Products
   Luperox DI  Di Tertiary Butyl Peroxide (DTBP)
   Luperox K3  Acetyl Acetone Peroxide (AAP)  • Benzoyl Chloride
   Luperox 500R  Di Cumyl Peroxide (DCP)  • Acetyl Chloride  Separation Technology
   Luperox DTAP  Di Tertiary Amyl Peroxide (DTAP)  • Chloroacetyl Chloride
   Luperox LP  Di Lauroyl Peroxide (LPO)  • Benzotrichloride              where dimer impurities are encountered.
 • Propionyl Chloride
   Luperox 101     2,5-Dimethyl 2,5-Di (tert. Butyl Peroxy) Hexane  • Hydrochloric Acid  Homogeneous catalyst recovery can be
   Luperox ANS  Benzoyl Peroxide Paste  • Toluene-Drum Packing            conveniently handled and a large number
   Luperox 331M50  1,1-Di-(tert. Butyl Peroxy) Cyclohexane  • Benzoic Acid-Technical Grade  of such catalysts are listed and pertinent
 ROMA ORGANICS PVT. LTD.  • 5-Chlorosalicylic Acid (25KG & 50KG)          references are given including for
 Offi ce No. 604, Devavrata, Sector-17, Vashi, Navi Mumbai 400 703.        metathesis reaction.
 Tel.: 022-2765 7576 / 6791 3432  Fax: 022-2788 0227  Email: romachem@gmail.com
                                                                          OSNF assisted peptide and oligonucleo-
                                                                          tide synthesis is covered.
 Stratechem (I) Pvt. Ltd.                                                 In pharma industries solvent exchange

                                                                          is encountered and OSNF is very useful
                                                                          and an example is given. An example of
 Speciality Chemicals   Ortho Toluene Para Toluene    4-(Dimethylamino)-Benzoic Acid   replacement of DMF with EtOH is also
  Ammonium Benzene Sulfonate  Sulfonamide Mixture  2 Butoxyethyl Ester
  Anisole   Para Chloro Benzene Sulfonamide   4-(Dimethylamino)-Benzoic Acid Ethyl Ester  given. Examples of cost saving are given.
  Benzene Sulfonic Acid   Para Chloro Benzene Sulfonate (Sodium Salt)   2,2-Dimethoxy-1,2-Diphenylethanone
  Benzene Sulfonyl Chloride   Para Chloro Benzene Sulfonyl Chloride   Phenylglyoxylicacid Methyl Ester  There is a summary of current challenges
  2-Benzoyl Benzoic Acid   Para Toluene Sulfonyl Chloride   4- Methyl Benzophenone  Membranes based   and some are covered in this column.   and possible solutions is reported. Recent
  4-Chloro Benzophenone   Phenyl Acetyl Chloride  separation  Major developments in making OSNF   research on membranes with enhanced
  Diphenyl Sulfide   Sodium Benzene Sulfonate  Thio Compounds  are covered in this exhaustive paper and   stability or better selectivity is covered.
  Diphenyl Sulfone   2-(Dimethylamino) Ethylbenzoate   Isopropyl Thiophenol  different modes of operations and models
  Methane Sulfonic Anhydride   2-Benzoylbenzoicacid Methyl Ester   4-Mercapto Phenol  Organic Solvent   are discussed. Commercially available   Enantiomeric separation membranes are
  Methyl Benzene Sulfonate   2-Ethylanthraquinone   Para Chloro Thiophenol  Nanofi ltration (OSNF) in   covered.
  Methyl Para Toluene Sulfonate   4-Benzoyl-4-Methyl Diphenyl Sulphide   Para Thiocresol  pharmaceutical applications  OSNF are reported.
  Ortho Toluene Sulfonamide   4-Phenylbenzophenone   Thio Phenol  The enrichment of pharma compounds   There are more than 110 references.
 Address: 92, Venus, Altamount Road, Mumbai 400 026.  H. Xiao et al have given an exhaustive   such as antibiotics, intermediates and pep-  [Org.Proc.Res.Dev, 2024, DOI:10.1021/
 Tel.: +91-22-66627509 / + 91 -22-66624572  Email: info@stratechem.in  www.stratechem.in  account of the usefulness of OSNF in   tides is one of the classical applications.   acs.oprd.3c00470].
       pharma industries and anyone interested   Even dilute natural extracts can be con-
       in this area must read this paper. The   centrated. Example include Spiramycin,   Could drug availability be
 MANUFACTURERS AND EXPORTERS OF  MANUFACTURER & SUPPLIER OF   key advantages of OSNF are that it can   Clarithomycin, Levofl oxacin, Rifampi- improved through shape
 QUETIAPINE INTERMEDIATES:    Zinc Sulphate Mono Hydrate (33%)  sieve molecules having typically mol. wt.   cin, etc. A sharp molecular weight cutoff    modifi cation?
  2-(2-Chloroethoxy)ethanol (CAS NO: 628-89-7)  Zinc Sulphate Hepta Hydrate (21%)  above 250 and even highly polar solvents   of around 300 Da is reported.
  1-[2-(2-Hydroxyethoxy)ethyl]piperazine (CAS NO:13349-82-1)  Ferrous Sulphate Mono Hydrate (31%)  can be handled with the advent of new   API purifi cation is discussed at length and   J.P. Kardum  et al have studied the
 PENTOXYFYLLINE AND PROPENTOFYLLINE   Ferrous Sulphate Hepta Hydrate (19%)  polymers. This is all done at ambient   impurities can be organic, inorganic im-  possibility of spherical agglomeration
       conditions and is highly energy effi cient.
 INTERMEDIATES:    Copper Sulphate Penta Hydrate (24%)  A large number of examples are given   purities and residual solvents. Genotoxic   for two API from different classes of
  6-Chloro-2-Hexanone (CAS NO: 10226-30-9)  Manganese Sulphate Mono Hydrate (30.5%)  impurities removal has received attention.   Biopharmaceutical classifi cation system.
                                                                          Dronedarone hydrochloride and certinib
 OTHER PRODUCTS:  Magnesium Sulphate Hepta Hydrate (9.6%)  Membrane cascades are discussed to   were investigated. Light and stereo-
                                         improve recovery.
  Gallic Acid (CAS NO: 149-91-7)  Magnesium Sulphate Mono Hydrate (15%)  microscopy were used to determine
  Pyrazole (CAS NO : 288-13-1)  Only for Agriculture Grade  Hybrid processes, which combine the
                                         advantages of OSNF and adsorption, are
 Please Contact: Archana Patil  R A J    discussed. The removal of oligomeric
 ghc industries  AGRO  RAJ AGRO          impurities is covered; e.g. reduction of
 Mulund (W). Mumbai. 400080. Maharashtra.  Plot No - 3 & 4, GIDC Gozariya - 384470, Mehsana, Gujarat, India.  substituted aromatic nitro compounds
 Email: archana.p5371@gmail.com / infoghcind@gmail.com  Ph : 02763 264555 | Fax : 02763 264555   reduction to the corresponding amines
 Mobile : 94270 58844 | Email: ketankumar.dave@yahoo.in
 Mobile: 9967535371 /  9930535969  Website: www.rajagro.co.in
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       Chemical Weekly  June 25, 2024                                                                  171

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