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ROMA ORGANICS PVT. LTD.                                                                                                                                                Special Report
                                  Auth. Distributors of:
                         M/s. Arkema Peroxides (I) P. Ltd.
         Luperox TBH70     Tertiary Butyl Hydro Peroxide (TBHP)
         Luperox CU90      Cumene Hydro Peroxide (CHP)                                                               A rapid wrap-up of what’s new in Operations,
         Luperox P         Tertiary Butyl Per Benzoate (TBPB)
         Luperox A75       Benzoyl Peroxide (BPO)                                                                    Processes and Products
         Luperox DI        Di Tertiary Butyl Peroxide (DTBP)
         Luperox K3        Acetyl Acetone Peroxide (AAP)                   • Benzoyl Chloride
         Luperox 500R      Di Cumyl Peroxide (DCP)                         • Acetyl Chloride                         Separation Technology
         Luperox DTAP      Di Tertiary Amyl Peroxide (DTAP)                • Chloroacetyl Chloride
         Luperox LP        Di Lauroyl Peroxide (LPO)                       • Benzotrichloride                                                                                            where dimer impurities are encountered.
                                                                           • Propionyl Chloride
         Luperox 101       2,5-Dimethyl 2,5-Di (tert. Butyl Peroxy) Hexane  • Hydrochloric Acid                                                                                          Homogeneous catalyst recovery can be
         Luperox ANS       Benzoyl Peroxide Paste                          • Toluene-Drum Packing                                                                                        conveniently handled and a large number
         Luperox 331M50    1,1-Di-(tert. Butyl Peroxy) Cyclohexane         • Benzoic Acid-Technical Grade                                                                                of such catalysts are listed and pertinent
                   ROMA ORGANICS PVT. LTD.                                 • 5-Chlorosalicylic Acid (25KG & 50KG)                                                                        references are given including for
            Offi ce No. 604, Devavrata, Sector-17, Vashi, Navi Mumbai 400 703.                                                                                                            metathesis reaction.
        Tel.: 022-2765 7576 / 6791 3432  Fax: 022-2788 0227  Email: romachem@gmail.com
                                                                                                                                                                                         OSNF assisted peptide and oligonucleo-
                                                                                                                                                                                         tide synthesis is covered.
                              Stratechem (I) Pvt. Ltd.                                                                                                                                   In pharma industries solvent exchange

                                                                                                                                                                                         is encountered and OSNF is very useful
                                                                                                                                                                                         and an example is given. An example of
          Speciality Chemicals             Ortho Toluene Para Toluene      4-(Dimethylamino)-Benzoic Acid                                                                              replacement of DMF with EtOH is also
           Ammonium Benzene Sulfonate     Sulfonamide Mixture              2 Butoxyethyl Ester
           Anisole                        Para Chloro Benzene Sulfonamide   4-(Dimethylamino)-Benzoic Acid Ethyl Ester                                                                given. Examples of cost saving are given.
           Benzene Sulfonic Acid          Para Chloro Benzene Sulfonate (Sodium Salt)   2,2-Dimethoxy-1,2-Diphenylethanone
           Benzene Sulfonyl Chloride      Para Chloro Benzene Sulfonyl Chloride   Phenylglyoxylicacid Methyl Ester                                                                    There is a summary of current challenges
           2-Benzoyl Benzoic Acid         Para Toluene Sulfonyl Chloride   4- Methyl Benzophenone                 Membranes based                   and some are covered in this column.   and possible solutions is reported. Recent
           4-Chloro Benzophenone          Phenyl Acetyl Chloride                                                   separation                        Major developments in making OSNF   research on membranes with enhanced
           Diphenyl Sulfide               Sodium Benzene Sulfonate       Thio Compounds                                                              are covered in this exhaustive paper and   stability or better selectivity is covered.
           Diphenyl Sulfone               2-(Dimethylamino) Ethylbenzoate   Isopropyl Thiophenol                                                    different modes of operations and models
           Methane Sulfonic Anhydride     2-Benzoylbenzoicacid Methyl Ester   4-Mercapto Phenol                   Organic Solvent                   are discussed. Commercially available   Enantiomeric separation membranes are
           Methyl Benzene Sulfonate       2-Ethylanthraquinone            Para Chloro Thiophenol                  Nanofi ltration (OSNF) in                                            covered.
           Methyl Para Toluene Sulfonate   4-Benzoyl-4-Methyl Diphenyl Sulphide   Para Thiocresol                 pharmaceutical applications       OSNF are reported.
           Ortho Toluene Sulfonamide      4-Phenylbenzophenone            Thio Phenol                                                               The enrichment of pharma compounds   There are more than 110 references.
                                  Address: 92, Venus, Altamount Road, Mumbai 400 026.                                H. Xiao et al have given an exhaustive   such as antibiotics, intermediates and pep-  [Org.Proc.Res.Dev, 2024, DOI:10.1021/
                      Tel.: +91-22-66627509 / + 91 -22-66624572  Email: info@stratechem.in  www.stratechem.in      account of the usefulness of OSNF in   tides is one of the classical applications.   acs.oprd.3c00470].
                                                                                                                     pharma industries and anyone interested   Even dilute natural extracts can be con-
                                                                                                                     in this area must read this paper. The   centrated. Example include Spiramycin,   Could drug availability be
                    MANUFACTURERS AND EXPORTERS OF                            MANUFACTURER & SUPPLIER OF             key advantages of OSNF are that it can   Clarithomycin, Levofl oxacin, Rifampi- improved through shape
        QUETIAPINE INTERMEDIATES:                                              Zinc Sulphate Mono Hydrate (33%)      sieve molecules having typically mol. wt.   cin, etc. A sharp molecular weight cutoff    modifi cation?
         2-(2-Chloroethoxy)ethanol (CAS NO: 628-89-7)                         Zinc Sulphate Hepta Hydrate (21%)     above 250 and even highly polar solvents   of around 300 Da is reported.
         1-[2-(2-Hydroxyethoxy)ethyl]piperazine (CAS NO:13349-82-1)         Ferrous Sulphate Mono Hydrate (31%)     can be handled with the advent of new   API purifi cation is discussed at length and   J.P. Kardum  et al have studied the
        PENTOXYFYLLINE AND PROPENTOFYLLINE                                   Ferrous Sulphate Hepta Hydrate (19%)    polymers. This is all done at ambient   impurities can be organic, inorganic im-  possibility of spherical agglomeration
                                                                                                                     conditions and is highly energy effi cient.
        INTERMEDIATES:                                                        Copper Sulphate Penta Hydrate (24%)    A large number of examples are given   purities and residual solvents. Genotoxic   for two API from different classes of
         6-Chloro-2-Hexanone (CAS NO: 10226-30-9)                         Manganese Sulphate Mono Hydrate (30.5%)                                     impurities removal has received attention.   Biopharmaceutical classifi cation system.
                                                                                                                                                                                         Dronedarone hydrochloride and certinib
        OTHER PRODUCTS:                                                     Magnesium Sulphate Hepta Hydrate (9.6%)                                    Membrane cascades are discussed to   were investigated. Light and stereo-
                                                                                                                                                       improve recovery.
         Gallic Acid (CAS NO: 149-91-7)                                    Magnesium Sulphate Mono Hydrate (15%)                                                                        microscopy were used to determine
         Pyrazole (CAS NO : 288-13-1)                                                  Only for Agriculture Grade                                     Hybrid processes, which combine the
                                                                                                                                                       advantages of OSNF and adsorption, are
                           Please Contact: Archana Patil                     R A J                                                                     discussed. The removal of oligomeric
                           ghc industries                                    AGRO     RAJ AGRO                                                         impurities is covered; e.g. reduction of
                      Mulund (W). Mumbai. 400080. Maharashtra.             Plot No - 3 & 4, GIDC Gozariya - 384470, Mehsana, Gujarat, India.           substituted aromatic nitro compounds
                Email: archana.p5371@gmail.com / infoghcind@gmail.com      Ph : 02763 264555 | Fax : 02763 264555                                      reduction to the corresponding amines
                                                                           Mobile : 94270 58844 | Email: ketankumar.dave@yahoo.in
                         Mobile: 9967535371 /  9930535969                  Website: www.rajagro.co.in
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       170                                                                     Chemical Weekly  June 25, 2024        Chemical Weekly  June 25, 2024                                                                  171

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