Page 178 - CW E-Magazine (18-2-2025)

Continuous Manufacturing

Bibliography
1. Care for aging populations globally –
The Lancet Healthy Longevity.
2. Directed evolution: Past, present, and
future – Cobb – 2013 – AIChE Journal –
Wiley Online Library.
3. Full article: High-entropy materials
for electrocatalytic applications: a
review of fi rst principles modeling
and simulations (tandfonline.com).
4. Possibilities of process intensifi cation
using microwaves applied to catalytic
microreactors – ScienceDirect.
5. BJOC – Continuous fl ow nitration in
miniaturized devices (Beilstein-jour-
nals.org).
6. Scalable Continuous Synthesis of
A chemist, chemical engineer, mechanical engineer and pharmaceutical technologist setting up Grignard Reagents from in Situ-Acti-
a novel fl ow reactor system at the Amar Flow Laboratory LLP premises in Mumbai. vated Magnesium Metal | Organic
manufacturing is challenging. The know what the on-ground challenges Process Research & Development
initial capital investment required for are. It can only happen if the various (acs.org).
new equipment and infrastructure can experts constantly educate each other 7. https://www.fi ercepharma.com/man-
be substantial, particularly for com- on what is feasible and what is not. ufacturing/novartis-erects-3rd-radio-
panies with established batch manu- Companies should encourage their therapy-facility-us-brings-isotope-
facturing facilities. Additionally, the experts to get out of the silos artifi - production-house-amid.
complexity of developing and scaling cially created by separate departments 8. https://www.novartis.com/stories/
continuous processes, not just those housed in individual offi ces and mix new-drug-manufacturing-tools-
involving new technologies like bio- talents to get multi-disciplinary teams change-pharma-chemistry.
catalysis and electrifi cation but also and give them the resources and time 9. https://connectedmanufacturing.
more mundane, established chemis- to succeed. wbresearch.com/blog/pfizer-new-
tries, requires signifi cant engineering continuous-manufacturing-plant-
expertise and resources in time and CONCLUSION strategy.
effort. Regulatory approval processes The long-term benefi ts of continu-
may also be more complex, as continu- ous green manufacturing are compel- DR. VISHWANATH H. DALVI
ous manufacturing methods are still ling. Companies that successfully Advisor – Flow Technology
relatively new in the pharmaceutical adopt these methods stand to gain from Amar Equipment Pvt. Ltd.
industry, and ensuring compliance reduced operational costs and environ- Faculty, Institute of Chemical Technology
with Good Manufacturing Practices mental impact and enhanced market
(GMP) can be challenging. positioning as leaders in sustainability. DR. CHANDRAKANTH R.
Furthermore, as regulatory pressures GADIPELLY
A less appreciated challenge is and consumer demand for sustainable Principal Research Scientist
the creation of “silos” of expertise in products continue to grow, early adopt- R&D – Flow Chemistry
cash-rich companies. We need chemists, ers of continuous green manufacturing Amar Equipment Pvt. Ltd.
chemical engineers, mechanical engi- will be well-positioned to capitalize Email: Chandrakanth.Gadipelly@amarequip.com
neers, control and instrumentation on these trends. The keys to execut-
engineers, fabrication experts, and ing continuous green manufacturing MR. DARSHAN CHHEDA
economists at the same table. The are judiciously incentivized multidisci- Process Engineer – R&D – Flow Chemistry
literature does not capture all of this plinary teams that are empowered with Amar Equipment Pvt. Ltd.
expertise – fabricators hardly publish the time and resources to deploy inno- Email: Darshan.Chheda@amarequip.com
their work. So, the LLMs will never vative solutions.

178 Chemical Weekly February 18, 2025

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