Page 187 - CW E-Magazine (16-4-2024)

Special Report

usual manufacture of large stirred ves-
sels. The process is more automated
and reliable, monitoring is facile, and
manual intervention is minimised.
However, it makes many demands. It
requires a thorough, quantitative under-
standing of the process and the equip-
ment. It requires constant, respectful
communication between members of a
highly trained, motivated, multi-discip-
linary team to anticipate and forestall
disruptions and plan and execute shut-
downs and startups meticulously. It
requires access to a good, knowledge-
able fabrication partner.

While batch processing is the com-
fort zone for chemical manufacturing
right now, the future is clearly in flow.
Chemical manufacturers should start
transitioning their processes to flow as
soon as possible. This process begins
with transitioning the culture in these
organisations to one in which front-line
workers, engineers, and technologists
feel empowered to actively participate https://doi.org/10.1021/acs. fits and Requirements (leanmanu-
in the innovative process and feel secure chemrev.7b00183. facturingtools.org).
enough to learn from colleagues with a 2. Q13 Continuous Manufacturing of 5. Nitration Chemistry in Continuous
different background and skills. Drug Substances and Drug Products Flow using Fuming Nitric Acid in a
| FDA. Commercially Available Flow Re-
reFerences 3. https://www.nascar.com/. actor | Organic Process Research &
1. Plutschack et al, Chem. Rev. 2017 4. Just in Time JIT Production; Bene- Development (acs.org).

Chemical Weekly April 16, 2024 187

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