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Special Report                                                                                                                                                                   Special Report



       EPA announces winners of the 2024 Green Chemistry                                                             microbial pesticide for crops including  9.9 out of 10, noting that the Pro Farm  cal granules of phosphate rock with
                                                                                                                     corn,  cotton,  soy,  and  wheat.  RinoTec  Group’s  documentation also showed  other materials that improve phosphate
       Challenge Awards                                                                                              is based on a microbe with natural pesti-  minimal soil, aquatic, and human toxicity  availability for plants.  The additional
                                                                                                                     cidal effects. Bioceres has engineered  as well as minimal ecosystem impacts  materials allow the tricalcium phos-
                                                                                                                           Target Your Market More Effectively
                                                                                                                     the growth of this microbe to produce  and harmful materials.       phate in the phosphate rock, which is not
             n September 26, the U.S. Environ  the starting point. The new method uses  that works by increasing the ability of   more of the natural pesticide compound,                available to plants, to be converted into
             mental  Protection Agency  a heterogeneous (i.e., solid) catalyst,  the body’s immune system to help detect   which reduces the application rate for  Specifi c Environmental Benefi t –   available forms in the soil. This avoids
                                                                                                                                  ChemImpex
                                                                                                                                                                                IndiaChemTrade
       O(EPA)  announced the winners  which reduces the amount needed and  and fi ght tumour cells. Typically, these   RinoTec. The microbe is grown in large  Climate Change: PhoSul, Sugar City,   traditional phosphate processing in
       of the 2024 Green Chemistry Challenge  also avoids hard reaction conditions of  types of proteins are produced in large   vessels, then killed and incorporated into  Idaho  Free for subscribers of Chemical Weekly
                                                                                                                                                                                         chemical plants, where strong acids like
                                                                                                                                    For subscribers only
       Awards for new and innovative green  existing bio-based lubricant production.  batches. Merck now uses a continuous   a seed treatment package that coats the   PhoSul is being recognized for deve-  sulphuric acid are used to convert the
                                                                                                                      ChemImpex, the trade database, tracks, on a daily
                                                                                                                                                                       IndiaChemTrade provides consolidated trade statistics
       chemistry technologies.  This year’s  Professor  Vlachos’s team has developed  process to produce pembrolizumab, in   seeds prior to planting. According to Pro  loping enhanced phosphate rock ferti-  tricalcium phosphate into a usable form.
                                                                                                                                                                       of India. The information provided here is based on the
                                                                                                                      basis, exports and imports of chemicals and related
       winners have developed chemical  three classes of bio-lubricant base oils  which the protein is fi ltered away from   Farm Group, RinoTec  is “readily bio-  lizer, which avoids hazards associated  Acid processing generates hazardous
                                                                                                                      products through the major ports in India — a vital
                                                                                                                                                                       annual trade data published by the Directorate General
       products and processes that reduce or  with different  properties, which they  the cells continuously instead of per-  degradable” and can replace several com-  with traditional phosphate  fertilizer  gypsum waste, which contains concen-
       eliminate the generation and use of  found can provide comparable or better  forming a one-time fi ltration step at the   monly used synthetic pesticide products.  production and improves performance  trated heavy metals and radionucleides
                                                                                                                      source of commercial intelligence. Find out on-line
                                                                                                                                                                       of Commercial Intelligence and Statistics, Government
       hazardous substances, use less energy,  performance to existing technologies.  end of a batch. This process can produce   how international markets are moving; where your   of India. The database can be searched by: Chemical
                                                                                                                                                       compared to existing rock  fertilizers.  from the phosphate rock and can release
       and are more sustainable.                                          substantially more pembrolizumab per        competitors are exporting and at what price; where   Name/Harmonised Code to obtain the consolidated
                                                                                                                        RinoTec is an improvement to their  Phosphate  fertilizers improve crop  fl uorine into the atmosphere in fl uorine-
                                         Small Business Award: Viridis    reactor volume, which allows Merck to      prior product called BIOst, a nematicide  health  and yield, but need to be in  containing  gasses  such  as  hydrofl uoric
                                                                                                                                                                       trade (import or export) in that item; or by Country to
                                                                                                                      imports are coming from and how their prices are
          An independent panel of techni-  Chemical Company               use smaller equipment and thus shrinks     and insecticide based on the microbe  specifi c  forms  to  be  usable  by  plants.  acid. Further, PhoSul minimizes phos-
                                                                                                                                                                       obtain the trade (import or export) in all chemicals and
                                                                                                                      moving. Download all this data, seamlessly, for a
       cal experts convened by the American   Viridis Chemical Company is being  the  facility’s  physical footprint,  reducing   Burkholeria rinojensis. Unlike BIOst,  Currently, usable  phosphate is pro-  phate leaching in the fi eld, eliminating
                                                                                                                      small fee — online, anytime, with no hassles.
                                                                                                                                                                       related products between India and that country
       Chemical Society Green Chemistry  recognized for developing a process  the facility’s energy use. The continuous   which requires relatively high applica-  duced from phosphorus-containing  phosphate runoff and its associated
       Institute  formally  judged the  2024  for making renewable ethyl acetate, a  process also reduces the  energy and   tion rates, for RinoTec, Pro Farm Group  rock, which must be processed with  ecological damage.
                                                                                                                                                         ChemXchange
       submissions and made recommenda-  common chemical that has traditionally  water needed, as well as using consum-  engineered the fermentation to increase  strong acids, creating a waste (gypsum)
                                                                                                                                               Open to all registered users — no subscription required
       tions to EPA.                     relied on fossil fuel feedstocks. Viridis  ables  (such  as  fi lters)  more  effi ciently.   the production of the key pesticidal  that is contaminated with heavy metals  Nominations invited for 2025 awards
                                                                                                                      ChemXchange — the chemical exchange with a difference — is where you can identify your buyers and sup-
                                         developed a catalyst that allows them  Reducing the amount of energy and    metabolite, allowing substantially reduced  and radioactive material from the raw   EPA is currently accepting  nomi-
                                                                                                                      plyers on-line, any time. This unique platform is free to all advertisers in the print version of Chemical Weekly.
       Academic Category: University of   to produce ethyl acetate from corn ethanol  water the facility uses prevents pollution   application rates, thereby reducing the  material. PhoSul has developed a method  nations for the 2025 Green Chemistry
       Delaware, Professor Dionisios     instead of from chemicals acquired  by leading to fewer air emissions.      amount of this product being released  to use phosphate  rock directly  by  Challenge Awards, from companies or
       G. Vlachos                        from processing coal or natural gas. The                                    into the environment. For more information contact: 022-24044477. Fax: 022-24044450
                                                                                                                                                       enhancing it with other materials,  institutions that have developed a new
          Professor Dionisios G.  Vlachos is  process also produces hydrogen gas as   The continuous process can produce         Email: corporate@chemicalweekly.com or log on to chemicalweekly.com
                                                                                                                                                       avoiding the need for  acid processing  green chemistry process or product
       being recognized for developing new  a byproduct, which is used to generate  substantially more pembrolizumab per   A life cycle assessment by Bound-  and the associated wastes.  that helps protect human health and the
       synthetic methods to produce lubricant  about 40% of the energy needed to  reactor volume, which allows Merck to   less Impact Research and  Analytics                            environment. Nominations are due to
       base oils from renewable feedstocks.  operate the  plant,  thus reducing  the  use smaller equipment and thus shrinks   scored the  BIOst pesticide product a   PhoSul’s fertilizer consists of spheri-  EPA by Friday, Dec. 13, 2024.
       Lubricant base oils are the main com-  plant’s energy needs and therefore green-  the  facility’s  physical footprint.  The
       ponent of lubricants and are used in  house gas emissions and emissions of  smaller physical footprint of the facility
       many applications, including machinery  other hazardous substances, pollutants,  helps prevent pollution because Merck
       and vehicles. The new technology uses  or contaminants associated with energy  is able to reduce energy consumption
       biomass (e.g., plants or food waste) to  production.               and therefore air emissions.
       produce the lubricant base oils instead
       of traditional petroleum-based mate-  The reaction uses a solid-state cata-  Merck estimates this continuous                                      Missed a copy !!!
       rials. The process also eliminates some  lyst, allowing reclamation of the catalyst  manufacturing single-use process    For Digital Edition of this month’s issue & all other past issues
       hazardous reagents, including corrosive  constituents at end of life. It produces  reduces energy consumption for Keytruda
       acids, used in the traditional synthesis.  high-purity ethyl acetate, which pro-  synthesis by about 4.5-fold; reduces
                                         vides a drop-in replacement for fossil  water use by 4-fold; and reduces raw                          Visit www.hpicindia.com
          Lubricant base oils make up about  fuel-based ethyl acetate.    material usage by about 2-fold, thus
       75-90% of commercially formulated                                  reducing energy use and greenhouse
       lubricants. They represent about a $60-bn  Greener Synthetic Pathways: Merck &   gases for the facility.                                  PDF copies available for download
       market and are used in a variety of  Co., Inc.                                                                                                       Register Now
       applications, such as industrial machi-  Merck & Co., Inc. is being recog-  Design of Safer and Degradable                                                Mrs. Usha S. - usha@hpicindia.com
       nery and vehicles. Traditionally, lubricant  nized  for  developing  a  new  “continu-  Chemicals: Pro Farm Group, a Subsi-  Contact: For Subscription  : Mrs. Usha S. - usha@hpicindia.com
       base oils have been synthesized from  ous process” for manufacturing its PD-1  diary of Bioceres Crop Solutions
       petroleum feedstocks. The new process  therapy,  Keytruda (pembrolizumab).   Bioceres is being recognized for the                        For Advertising  : Mr. Vijay Raghavan - vijay@hpicindia.com
       uses biobased feedstocks, with sugars as  Pembrolizumab  is  an  immunotherapy  development of  RinoTec™, an enhanced
       170                                                                   Chemical Weekly  October 29, 2024       Chemical Weekly  October 29, 2024                                                               171

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