Page 47 - CW E-Magazine (24-10-2023)

Sapala Organics Private Limited UPARNA Introducing Established in 1980
Lithium Alkoxides, Li Tertiary Butoxide,
Turning Chemistry into Reality......... ISO 9001:2015 Accredited Company Li Hexamethyldisilazide & LiHMDS/THF 24-26%
SUPARNA CHEMICALS LIMITED
An unique organisation where both excellence in synthetic skills & state-of-the-art
analytical support coexist under single roof offering seamless services to the academic & Potassium Alkoxides & Amides Sodium Alkoxides & Amides
industrial customers
FOCUS AREAS OF SAPALA Potassium Tertiary Butoxide (KTB) 99% Sodium Tertiary Butoxide (STB) 99%
MEDICINAL CHEMISTRY NUCLEOSIDE CHEMISTRY
• Sodium Tertiary Butoxide in Tetrahydrofuran (20%) • Potassium Tertiary Butoxide in Tertiary Butanol (15%) • Sodium Tertiary Butoxide in Tetrahydrofuran (20%)
Nucleosides & Amidites
Drug Discovery / Lead Optimisation • Sodium n-Butylate (SNB) in n-Butanol (19%) • Potassium Tertiary Butoxide in Iso Butanol (19%) • Sodium n-Butylate (SNB) in n-Butanol (19%)
Scaffold Synthesis Carbohydrate & Lipids • Potassium Tertiary Butoxide in Iso Propanol (29%)
Fluorescent Dyes
Library Molecules • Sodium Iso Propylate (SIP) in THF (20%) • Potassium Tertiary Butoxide in Tetrahydrofuran (20%) • Sodium Iso Propylate (SIP) in THF (20%)
Synthesis of Reference Standards & Impurities • Sodium n-Propylate (SNP) in n-Propanol (20%) • Sodium n-Propylate (SNP) in n-Propanol (20%)
Linker & Spacers for Oligonucleotides
Process Development for Lead Compounds Phosphorylation Chemistry (NTP) • Potassium n-Butylate (KNB) in n-Butanol (20%)
• Sodium Tertiary Amylate (STA) (98%)
ANALYTICAL SERVICES • Potassium Iso Propylate (KIP) in Iso Propanol (19%) • Sodium Tertiary Amylate (STA) (98%)
• Potassium n-Propylate (KNP) in n-Propanol (20%)
• Sodium Tertiary Amylate (STA) in Toluene (25%) • Sodium Tertiary Amylate (STA) in Toluene (25%)
THERMAL STUDIES &

SPECTROSCOPY CHROMATOGRAPHY WET ANALYSIS SPECIAL EQUIPMENT • Potassium Tertiary Amylate (KTA) (98%)

• Sodium Tertiary Amylate (STA) in Hexane (38%) • Potassium Tertiary Amylate (KTA) in Toluene (25%) • Sodium Tertiary Amylate (STA) in Hexane (38%)
NMR - 400 & 500 MHz HPLC - PDA, UV & RI Autotitrator DSC
TGA
LC-MS/LC-MS-MS HPLC- ELSD & CAD • Sodium Tertiary Amylate (STA) in • Potassium Tertiary Amylate in Tetrahydrofuran (50%) • Sodium Tertiary Amylate (STA) in
Gravimetric analysis
UPLC-MS Prep. HPLC Tetrahydrofuran (THF) (35%) Elemental analysis • Potassium Tertiary Amylate in Cyclohexane (5%) Tetrahydrofuran (THF) (35%)
Argentometric titration
GC-MS GC Coulometric Karl Fischer (C, H, N, S, O)
FTIR, UV, SOR GCHS Heavy metal ROI ICP-MS Potassium Methoxide in Methanol (25%) (Potassium Metal Route)
OLIGONUCLEOTIDES SERVICES
“All Your String of Beads in One Place” Sodium Potassium Alloy
With our expertise in Nucleic acid chemistry with more than 15 years of experience, we Potassium & Sodium Disilazanes
provide complete package for synthesis, process development and manufacturing of
oligonucleotides spanning from phosphoramidite synthesis to oligonucleotides
• Potassium Hexamethyl Disilazane (KHMDS) in THF (20% - 40%)
>50 years of combined experience in oligonucleotide and Phosphoramidite synthesis
“Scale of Synthesis from 1μmol to 12 mMol” • Potassium Hexamethyl Disilazane (KHMDS) in Toluene (15%)
• Sodium Hexamethyl Disilazane (SHMDS) in THF (20% - 40%)
Services Modalities
Alkoxides are also available at various concentrations in different solvents
Exploratory Research (Non-GMP)-Base Antisense Oligonucleotides (ASO)
backbone & sugar modificationst SiRNA
Process development Aptamer, miRNA Impure KCL Salt available
Toxicology and Pre-Clinical supply Conjugated oligos (lipid & GalNAc)
Analytical method development-Combination Morpholino Oligos Contact: SUPARNA CHEMICALS LIMITED
of orthogonal analytical techniques Primers, Probes & Fluorescent oligos 54-A, Mittal Tower, Nariman Point, Mumbai 400 021.
Tel: 022-22027446 w Fax: 022-22830212
BUSINESS MODELS Email: export@suparnachemicals.co.in, domesticsales@suparnachemicals.co.in
FTE-Based Contract Research FFS-Custom Synthesis Services Website: www.suparnachemicals.co.in
Contract Development & Manufacturing Organisations-CDMO Hyderabad Office: Contact: M/s. Commerce Centre Pharmachem LLP : Tel: 040-23413413 (3 lines)
Email: commercecentre.in@gmail.com
Sapala Organics Pvt Ltd. For any immediate need for Ketonic Resins
Plot Nos. 146B & 147, IDA Mallapur, Phase-II, Analytical servcies
Hyderabad, India -500076. • Ketonic Resin KTR 100 • Ketonic Resin KTR 123
Phone: +91-40-27170174, 75, 76 Contact on: +91-8978043456 & 9963111467 • Ketonic Resin KTR 118 • Ketonic Resin KTR 80

Email: info@sapalaorganics.com Email: customercare@sapalaorganics.com
Chemical Weekly October 24, 2023 47
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